{"id":85,"date":"2020-08-26T10:10:11","date_gmt":"2020-08-26T10:10:11","guid":{"rendered":"https:\/\/www.reusceltumor-cumcura.be\/?page_id=85"},"modified":"2020-08-26T10:45:07","modified_gmt":"2020-08-26T10:45:07","slug":"algemeen","status":"publish","type":"page","link":"https:\/\/www.reusceltumor-cumcura.be\/en\/algemeen\/","title":{"rendered":"General"},"content":{"rendered":"

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General<\/h1>\n

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What is a giant cell tumour?<\/h2>\n

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A\u00a0<\/span>giant cell tumour<\/span>\u00a0is a tumour that arises in connective tissue such as bone, muscle<\/span>\u00a0or around<\/span>\u00a0sinews.<\/span>\u00a0<\/span><\/p>\n

We distinguish between\u00a0<\/span>giant cell tumours<\/span>\u00a0of the bone and\u00a0<\/span>giant cell<\/span>t<\/span>umors<\/span>\u00a0in the weekly parts.<\/span>\u00a0<\/span><\/p>\n

To know with what kind of\u00a0<\/span>giant cell<\/span>t<\/span>umor<\/span>\u00a0you have to deal with,\u00a0<\/span>is\u00a0<\/span>tissue examination is needed. So, in addition to imaging studies (scans), it is usually necessary to take a sample of the tumour, a biopsy.<\/span>\u00a0<\/span><\/p>\n

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Connective tissue <\/strong>is the body's support tissue and has the following functions: protection of vital organs, strengthening of the body (bones or bone), shock absorber in joints (cartilage), insulation of the body (fatty tissue) and movement (muscles and tendons). Blood vessels and nerves are also partly composed of connective tissue.<\/span><\/p>\n

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What is a giant cell tumour of the bone?<\/h2>\n

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This tumour is also called a\u00a0<\/span><\/span><\/span>osteoclastoma<\/span><\/span>\u00a0<\/span>mentioned. A\u00a0<\/span><\/span><\/span>giant cell tumour<\/span><\/span>\u00a0<\/span>of the bone consists of oval cells with so-called giant cells between them (large cells with very many nuclei - where a cell normally has only one nucleus), hence the name. This type of tumour can affect the bone very severely and grows on into the surrounding area with fine offshoots (infiltrative growth), so it can rapidly recur if not completely removed. This is a benign tumour, meaning that in principle it does not spread to other sites. Nevertheless, metastases are seen in about 2% of patients\u00a0<\/span><\/span><\/span>origin<\/span><\/span>\u00a0<\/span>in the lungs on average after 3 to 4 years. These metastases usually grow very slowly.<\/span><\/span><\/span><\/p>\n

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What is a giant soft tissue cell tumour?<\/h2>\n

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The correct English term is Giant\u00a0<\/span>cell<\/span>\u00a0<\/span>tumour<\/span>\u00a0or\u00a0<\/span>tendon<\/span>\u00a0<\/span>sheath<\/span>, the Dutch-language name is\u00a0<\/span>Giant cell tumour<\/span>\u00a0of the tendon sheath. Other names are\u00a0<\/span>tenosynovial<\/span>\u00a0<\/span>giant cell tumour<\/span>, pigmented\u00a0<\/span>villonodular<\/span>\u00a0synovitis.<\/span>\u00a0<\/span><\/p>\n

These tumours are subdivided according to\u00a0<\/span>\u00a0<\/span><\/p>\n

    \n
  • <\/span>the place where they occur: inside or outside a joint\u00a0<\/span><\/span><\/li>\n
  • <\/span>their growth pattern: localised (a nicely rounded bulb) or diffuse (scattered, without a nice capsule around it).<\/span><\/span><\/li>\n<\/ul>\n

    The localised form is most common.<\/span>\u00a0<\/span><\/p>\n

    Tumours are composed of small cells with giant cells (=cells with very many nuclei, where an ordinary cell has only one nucleus) next to them. Other cells are also mixed in the tumour. These tumours are benign, meaning they will not spread to other parts of your body. However, they can have an aggressive behaviour locally, where they also start to grow into nearby soft tissue and\/or bone. They continue to grow into the surrounding area with small outgrowths, making them relatively likely to return after surgical treatment.<\/span>\u00a0<\/span><\/p>\n

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    Where and in whom do giant cell tumours occur?<\/h2>\n

    [\/et_pb_text][et_pb_divider colour=\"#e29c8d\" divider_weight=\"3px\" _builder_version=\"4.5.8\u2033 max_width=\"50px\" custom_margin=\"||0px\"][\/et_pb_divider][\/et_pb_column_inner][\/et_pb_row_inner][et_pb_row_inner _builder_version=\"4.5.8\u2033 width=\"100%\" width_tablet=\"80%\" width_phone=\"\" width_last_edited=\"on|tablet\" max_width=\"1080px\" custom_margin_tablet=\"|10%||10%||true\" custom_margin_phone=\"\" custom_margin_last_edited=\"on|tablet\" custom_padding=\"||1px|||\" module_alignment_tablet=\"centre\" module_alignment_phone=\"\" module_alignment_last_edited=\"on|tablet\" locked=\"off\"][et_pb_column_inner saved_specialty_column_type=\"3_4\u2033 _builder_version=\"3.25.3\u2033][et_pb_tabs _builder_version=\u201d4.5.8\u2033 custom_margin=\"-2px||31px|||\" border_radii=\"on|10px|10px|10px|10px|10px\" border_width_all=\"0px\" border_colour_all=\"#ffffff\" box_shadow_style=\"preset2\u2033][et_pb_tab title=\"Giant cell tumour of the bone\" _builder_version=\"3.27.4\u2033]<\/p>\n

    This<\/span>\u00a0<\/span>giant cell tumour<\/span>\u00a0is very rare, less than 2 people per million people per year develop such a tumour. The\u00a0<\/span>giant cell tumour<\/span>\u00a0represents about 20% of all benign tumours of the bone. Typically, patients are affected between 20 and 45 years of age, and about 10-15% are seen in adolescents with a mature skeleton.<\/span>\u00a0<\/span><\/p>\n

    Giant cell tumours<\/span>\u00a0usually occur at the ends of the long pipe bones, mostly around the knee (distal femur and proximal\u00a0<\/span>tibia<\/span>), at the level of the wrist (distal radius) and at the level of the shoulder (proximal\u00a0<\/span>humerus<\/span>). A\u00a0<\/span>giant cell tumour<\/span>\u00a0is in many cases located just below the cartilage of a joint, and can sometimes grow into the joint itself. Sometimes the spine is affected.<\/span><\/p>\n

    [\/et_pb_tab][et_pb_tab title=\"Giant cell soft tissue tumour\" _builder_version=\"3.27.4\u2033]<\/p>\n

    The\u00a0<\/span>giant cell tumour<\/span>\u00a0can occur at any age, but is most commonly seen between the ages of 30 and 50, more in women than in men.\u00a0<\/span>\u00a0<\/span><\/p>\n

    This localised form is most commonly diagnosed in the hand (85%), but also in the wrist, ankle and foot, and knee. It is very rarely seen in the\u00a0<\/span>elbow<\/span>\u00a0and the hip.<\/span>\u00a0<\/span><\/p>\n

    The diffuse type\u00a0<\/span>giant cell tumour<\/span>\u00a0is most commonly seen in the knee (75%) and hip (15%), but can also occur in the ankle, the\u00a0<\/span>elbow<\/span>\u00a0and the shoulder. Very rarely, the tumour is also found in the jaw joint or the small joints of the vertebrae (facets). This type\u00a0<\/span>giant cell tumour<\/span>\u00a0can also develop outside the joints, in the muscles or in the lower skin, and usually around the knee, in the thigh or in the foot.<\/span>\u00a0<\/span><\/p>\n

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    What is the cause of a giant cell tumour?<\/h2>\n

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    The cause of the emergence of a\u00a0<\/span>giant cell tumour<\/span>\u00a0in the bone is not known.<\/span>\u00a0<\/span><\/p>\n

    Also in soft tissue tumours, there is<\/span>\u00a0no single cause<\/span>. M<\/span>and suspects\u00a0<\/span>That it could be a consequence of a\u00a0<\/span>combination of genetic factors and possibly an inflammatory response at<\/span>\u00a0<\/span>As a result of trauma.<\/span>\u00a0<\/span><\/p>\n

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    What symptoms does it cause?<\/h2>\n

    [\/et_pb_text][et_pb_divider colour=\"#e29c8d\" divider_weight=\"3px\" _builder_version=\"4.5.8\u2033 max_width=\"50px\" custom_margin=\"||0px\"][\/et_pb_divider][et_pb_tabs _builder_version=\"4.5.8\u2033 custom_margin=\"30px||31px|||\"border_radii=\"on|10px|10px|10px|10px\" border_width_all=\"0px\" border_colour_all=\"#ffffff\" box_shadow_style=\"preset2\u2033][et_pb_tab title=\"Giant cell tumour of bone\" _builder_version=\"3.27.4\u2033]<\/p>\n

    You usually experience pain and see swelling. The pain may occur at rest (e.g. at night) or after loading. The more the bone is affected by the tumour, the more pain you will experience because the bone can no longer handle the load. Sometimes a spontaneous fracture of the bone occurs because the bone is so fiercely weakened. Deformities in a joint may make it harder for you to move this joint.<\/span><\/span>\u00a0<\/span><\/p>\n

    [\/et_pb_tab][et_pb_tab title=\"Giant cell soft tissue tumour\" _builder_version=\"3.27.4\u2033]<\/p>\n

    If it is a localised form, you usually see a painless swelling. This swelling grows slowly over a period of several years.\u00a0<\/span>\u00a0<\/span><\/p>\n

    The diffuse form gives rise to pain, swelling or reduced mobility. If the tumour is in a joint, it may give rise to bleeding or up-and-down swelling of this joint. The deterioration of the bone may also cause premature wear and tear of the joint. These symptoms are usually present for several years.<\/span>\u00a0<\/span><\/p>\n

    [\/et_pb_tab][\/et_pb_tabs][\/et_pb_column_inner][\/et_pb_row_inner][\/et_pb_column][\/et_pb_section]<\/p>","protected":false},"excerpt":{"rendered":"

    GeneralWhat is a giant cell tumour?A giant cell tumour is a growth that arises in connective tissue such as bone, muscle or around tendons. We distinguish between giant cell tumours of the bone and giant cell tumours in the soft tissue. To know which type of giant cell tumour you are dealing with, tissue examination is needed. So, in addition to imaging studies (scans), it is usually necessary to take a sample of the tumour, a biopsy. Connective tissue is the supporting tissue [...]<\/p>","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":""},"_links":{"self":[{"href":"https:\/\/www.reusceltumor-cumcura.be\/en\/wp-json\/wp\/v2\/pages\/85"}],"collection":[{"href":"https:\/\/www.reusceltumor-cumcura.be\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.reusceltumor-cumcura.be\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.reusceltumor-cumcura.be\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.reusceltumor-cumcura.be\/en\/wp-json\/wp\/v2\/comments?post=85"}],"version-history":[{"count":0,"href":"https:\/\/www.reusceltumor-cumcura.be\/en\/wp-json\/wp\/v2\/pages\/85\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.reusceltumor-cumcura.be\/en\/wp-json\/wp\/v2\/media?parent=85"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}